Cas<p130> (Crk-associated sucstrate p130)遺伝子のexon2からexon7のゲノムの位置にCas cDNAのcoding領域をloxPで挟んだものと置換してあるfloxマウス(p130Casの完全なconditional knockout mice) Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. Cas-FL conditional KO Cas-FL conditional KO 開発者／機関：本田浩章先生／広島大学原爆放射線医科学研究所開発年：2005年特記：寄託時の戻し交配数は3。 Cre/loxP system 国立大学法人広島大学 Necessary documents for ordering:<ol><li>Approval form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_6.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_d.docx">English</A>)</li><li>Order form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx">English</A>)</li><li>Category I MTA: MTA for distribution with RIKEN BRC (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx">English</A>)</li><li>Acceptance of responsibility for living modified organism (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx">English</A>)</li></ol><A HREF="https://www.twmu.ac.jp/ILA/" target="_blank">Lab HP (Japanese)</A> B6;129P2-p130Cas<tm2.1Homy> B6;129P2-p130Cas<tm2.1Homy> Hiroaki HONDA phage P1 loxP sites, rat Cas cDNA, SV40 poly A, yeast FRT site, mouse Cas genomic DNA RBRC02338 true Bcar1 (p130Cas) is an adaptor molecule on growth factor receptor and integrin activation functions as regulator of cell motility and invasion. This conditional knockout mice have a loxP-flanked Bcar1 allele. Conditional Bcar1 deficient mice can be generated by crossing with tissue-specific Cre mice. 本田　浩章 backcross to C57BL/6N (Heterozygote x C57BL/6NCrlCrlj) Hiroshima Univ. 戻し交配　Background系統：C57BL/6N（日本チャールズ・リバー） C（3〜6か月） FLP/frt system C (3-6 months) <a href='https://brc.riken.jp/mus/pcr02338'>Genotyping protocol -PCR-</a> 開発者／機関：本田浩章先生／広島大学原爆放射線医科学研究所 開発年：2005年 特記：寄託時の戻し交配数は3。 E14 [129P2/OlaHsd] 条件を付加する。利用者は提供承諾書を用いて、事前に寄託者の承諾を得る。 Developed by Dr. Hiroaki Honda, Hiroshima University in 2005.